HCID 23440960, compound → HCID 10112090, compound

HRID 2119982Notes

Reaction equation

HRID 2119982 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=O)[CH2:9][C:8]3[CH:13]=[N:14][C:15]([CH3:17])=[N:16][C:7]=3[C:6]=2[CH:18]=1.CN(C)[CH:21]=[N:22][CH2:23][C:24]1[CH:28]=[C:27]([CH3:29])[O:26][N:25]=1>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:11]3[C:10]([CH2:9][C:8]4[CH:13]=[N:14][C:15]([CH3:17])=[N:16][C:7]=4[C:6]=2[CH:18]=1)=[C:23]([C:24]1[CH:28]=[C:27]([CH3:29])[O:26][N:25]=1)[N:22]=[CH:21]3

Participants

3

Reactant 2

HCID 23440960HCID 23440960, compoundHCID 23440965HCID 23440965, compound

Product 1

HCID 10112090HCID 10112090, compound

Procedure

From 10-bromo-5,7-dihydro-2-methyl-6H-pyrimido[5,4-d][1]benzazepin-6-one according to scheme 1, step 7 using N,N-dimethyl-N′-(5-methyl-isoxazol-3-ylmethyl)-formamidine instead of (E)-(dimethylaminomethyleneamino)-acetic acid ethyl ester. Clear gum, m/z (ISP) 407/409 (MH)

Sources & evidence

ORD record
ord-aa38b16e58c2402bbe928c812fb56e24
Source dataset
uspto-grants-2004_02
Patent number
US06686352B2

Reaction notes

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