化工社化工社 化学情報印刷レポート · 研究参考用
Iodine → 7-Iodo-4-(4-tert-butyldimethylsilyloxyphenyl)isoindolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Nitric acid, 1,1-dimethylethyl ester | HCID 164756 | — |
| 反応物 | 7-Amino-4-(4-tert-butyldimethylsilyloxyphenyl)isoindolinone | HCID 68490022 | — |
| 触媒 | Copper iodide | HCID 83717 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 7-Iodo-4-(4-tert-butyldimethylsilyloxyphenyl)isoindolinone | HCID 68489422 | 47% |
反応手順
In a similar manner to Step 4 of Example 140, 7-amino-4-(4-tert-butyldimethylsilyloxyphenyl)isoindolinone (179 mg, 0.505 mmol) was dissolved in acetonitrile (12.5 mL), and the solution was treated with potassium iodide (133 mg, 0.808 mmol), copper iodide (152 mg, 0.808 mmol), iodine (203 mg, 0.808 mmol) and tert-butyl nitrate (0.127 mL, 1.06 mmol), followed by purification by flash column chromatography (chloroform) to obtain 7-iodo-4-(4-tert-butyldimethylsilyloxyphenyl)isoindolinone (109 mg, yield 47%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-9c45ea9b5aba425d9edc19e430596f45 |
| 出典メモ | uspto-grants-2010_06 |