Acetic Anhydride → 5-Bromo-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridine

HRID 2120107Notes

Reaction equation

HRID 2120107 reaction equation
[NH:1]=[C:2]([NH:10][OH:11])[C:3]1[CH:8]=[CH:7][C:6]([Br:9])=[CH:5][N:4]=1.[C:12](OC(=O)C)(=O)[CH3:13]>>[CH3:12][C:13]1[O:11][N:10]=[C:2]([C:3]2[CH:8]=[CH:7][C:6]([Br:9])=[CH:5][N:4]=2)[N:1]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178513247HCID 178513247, compound

Product 1

HCID 234386105-Bromo-2-(5-methyl-1,2,4-oxadiazol-3-yl)pyridine

Procedure

In 250 ml of acetic anhydride was dissolved 8.6 g of 2-(imino-N-hydroxyaminomethyl)-5-bromopyridine and the solution was refluxed for one day. After completion of the reaction, the same post-treatment as in Preparation Example. 13 was conducted to give the title compound. 2.8 g.

Workup

  1. temperaturethe solution was refluxed for one day
  2. customAfter completion of the reaction

Sources & evidence

ORD record
ord-923fc21e24304369b1f93115c81b660e
Source dataset
uspto-grants-2004_02
Patent number
US06689779B2

Reaction notes

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