HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 5-broMo-2-(1,3-oxazol-5-yl)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Reactant | 5-Bromopyridine-2-carbaldehyde | HCID 9877562 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-broMo-2-(1,3-oxazol-5-yl)pyridine | HCID 23438598 | — |
Reaction Steps
In 5.4 ml of methanol was dissolved 200 mg of 5-bromo-2-formyl pyridine (5-bromo-2-pyridinyl aldehyde) which was then reacted with 231 mg of tosylmethylisocyanide for 3 hours in the presence of 178 mg of potassium carbonate under reflux. After completion of the reaction, the same post-treatment as in Preparation Example 13 was carried out to obtain the title compound. 204 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06689779B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-bfc06166e83b45df910b63412bc42684 |
| Source note | uspto-grants-2004_02 |