Nitric Acid → HCID 178524776, compound

HRID 2120127Notes

Reaction equation

HRID 2120127 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1.[N+:11]([O-])([OH:13])=[O:12]>S(=O)(=O)(O)O>[OH:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 178418479HCID 178418479, compound

Product 1

HCID 178524776HCID 178524776, compoundYield 36%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Procedure

To a solution of 30 g (0.217 mol) 6-hydroxy-nicotinic acid in 50 ml concentrated sulfuric acid was added 60 ml of a 1:1 mixture of conc. sulfuric acid and conc. nitric acid below 20° C. and stirred for 1 h at room temperature and afterwards heated to 80° C. for 4 h. The mixture was poured onto ice and the formed precipitate was collected and dried to yield 14.2 g (36%) of the title compound as a yellow amorphous solid.

Workup

  1. temperatureafterwards heated to 80° C. for 4 h
  2. additionThe mixture was poured onto ice
  3. customthe formed precipitate was collected
  4. customdried

Sources & evidence

ORD record
ord-639d9bd8ee4f4617b4f21335fab9b503
Source dataset
uspto-grants-2004_02
Patent number
US06689790B2

Reaction notes

Loading…