HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 6-amino-5-nitropyridine-3-carboxylate → Methyl 5,6-diaminopyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 6-amino-5-nitropyridine-3-carboxylate | HCID 13768248 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 5,6-diaminopyridine-3-carboxylate | HCID 9920476 | 94.5% |
Reaction Steps
A suspension of 5.97 g (30 mmol) 6-amino-5-nitro-nicotinic acid methyl ester in 30 ml methanol and 600 mg Pd/C (10%) cat was added and hydrogenated at room temperature during 14 h. The catalyst was filtered off and the solution was concentrated to yield 4.74 g (94%) of the title compound as white amorphous solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06689790B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-01b2b74bcddc49c298eceb3157c479f2 |
| Source note | uspto-grants-2004_02 |