Sodium borohydride → (1R,2S)-2-amino-3-methyl-1-phenyl-1-pentanol

Temperature

10 °C

The 2-(S)-amino-3-methyl-1-phenyl-1-pentanone hydrochloride (24.2 g, 0.106 mmol.) prepared above was dissolved in methanol (250 mL) The solution was stirred under chilling with ice to maintain the solution temperature at a temperature of lower than 10° C., and to this was portionwise added sodium borohydride (3.8 g, 0.10 mmol.) The reaction mixture was stirred for one hour at the same temperature, and concentrated under reduced pressure. To the residue were added chloroform (100 mL), water (50 mL), and 2N aqueous sodium hydroxide solution. The chloroform layer was separated, and the aqueous layer was subjected to extraction using chloroform The chloroform portions were combined, successively washed with water and aqueous saturated sodium chloride solution, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, to give the titled compound as a white crystalline product (17.8 g, yield: 87%)

1. temperatureunder chilling with ice
2. stirringwas stirred for one hour at the same temperature
3. concentrationconcentrated under reduced pressure
4. additionTo the residue were added chloroform (100 mL), water (50 mL), and 2N aqueous sodium hydroxide solution
5. customThe chloroform layer was separated
6. extractionthe aqueous layer was subjected to extraction
7. washsuccessively washed with water and aqueous saturated sodium chloride solution
8. dry with materialdried over anhydrous sodium sulfate
9. distillationThe solvent was distilled off under reduced pressure

ORD record

ord-7cd3199d8d2842fe9807ce76adde6252

Source dataset

uspto-grants-2004_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06689785B2