Hydrogen Bromide → HCID 12094545, compound

Participants

Reaction Steps

47% hydrobromic acid solution (1.6 ml) was added to 3-[6-(3-methoxyphenyl)benzo[b]furan-3-yl]pyridine (80 mg, 0.2655 mmol) obtained in Example 5, and the mixture was refluxed for 24 hours. After neutralizing with 2N sodium hydroxide aqueous solution and a saturated aqueous solution of sodium bicarbonate, and extracting with ethyl acetate, the organic layer was washed with water, then with saturated brine, and dried with anhydrous magnesium sulfate, followed by evaporating the solvent under reduced pressure. The product was crystallized in ether-chloroform to obtain a white powder of 3-[3-(3-pyridyl)benzo [b]furan-6-yl]phenol (58 mg, 76%).

Provenance & Evidence