4-tert-Butylbenzoyl chloride → HCID 12093896, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of the above 3-amino-N-(5-chloropyridin-2-yl)pyrazine-2-carboxamide (255 mg, 1 mmol) in pyridine (20 mL) was added 4-tert-butylbenzoyl chloride (402 mg, 86 mmol). The mixture was stirred for 36 hours at 55° C. It was cooled to room temperature then concentrated to dryness in vacuo. The residue was mixed with CH2Cl2 and purified by radial chromatography from which was recovered 85 mg (21%) of product.

Provenance & Evidence