Acetic Anhydride → 6-Acetamido-3-butyl-phthalide

HRID 2120179Notes

Reaction equation

HRID 2120179 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:12][CH2:13][CH2:14][CH3:15])[O:7][C:8]2=[O:9])=[CH:4][CH:3]=1.[C:16](OC(=O)C)(=[O:18])[CH3:17]>S(=O)(=O)(O)O>[C:16]([NH:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:12][CH2:13][CH2:14][CH3:15])[O:7][C:8]2=[O:9])=[CH:4][CH:3]=1)(=[O:18])[CH3:17]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 98777066-Amino-3-butyl-phthalide

Product 1

HCID 232747896-Acetamido-3-butyl-phthalide

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidCatalyst

Procedure

A mixture of 0.3 g (1.55 mmol) of compound obtained in Example 4 and 3 ml of acetic anhydride and 1 drop of sulphuric acid is heated until dissolved and kept for 15 minutes. On cooling, white crystals are separated and recrystallised from ethanol to give the title compound.

Workup

  1. temperatureis heated
  2. dissolutionuntil dissolved
  3. temperatureOn cooling
  4. customwhite crystals are separated
  5. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-81c4823dbdd94991bc66b6b331e39091
Source dataset
uspto-grants-2004_02
Patent number
US06689808B2

Reaction notes

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