6-Amino-3-butyl-phthalide → HCID 69883859, compound

HRID 2120181Notes

Reaction equation

HRID 2120181 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:12][CH2:13][CH2:14][CH3:15])[O:7][C:8]2=[O:9])=[CH:4][CH:3]=1>ClC(OCC)=O>[CH2:12]([CH:6]1[C:5]2[C:10](=[CH:11][C:2]([NH:1][C:8]([O:7][CH2:6][CH3:5])=[O:9])=[CH:3][CH:4]=2)[C:8](=[O:9])[O:7]1)[CH2:13][CH2:14][CH3:15]

Participants

3

Reactant 1

HCID 98777066-Amino-3-butyl-phthalide

Product 1

HCID 69883859HCID 69883859, compound

Reagents, catalysts & solvents 1

HCID 10928Ethyl chloroformateSolvent

Procedure

A mixture of 3.08 g (0.015 mol) of compound obtained in Example 4 and 10 ml of ethyl chloroformate is heated for 10 minutes. The excess ethyl chloroformate is removed in vacuo and the residue is washed with water and crystallised from dilute ethanol to give the title compound.

Workup

  1. temperatureis heated for 10 minutes
  2. customThe excess ethyl chloroformate is removed in vacuo
  3. washthe residue is washed with water
  4. customcrystallised from dilute ethanol

Sources & evidence

ORD record
ord-83f871d074334ef2b97f56c1d4fb2043
Source dataset
uspto-grants-2004_02
Patent number
US06689808B2

Reaction notes

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