6-Amino-3-butyl-phthalide → HCID 23439119, compound

HRID 2120185Notes

Reaction equation

HRID 2120185 reaction equation
[NH2:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]([CH2:12][CH2:13][CH2:14][CH3:15])[O:7][C:8]2=[O:9])=[CH:4][CH:3]=1>C1(=O)CCCCC1.C(O)C.[Pd]>[CH2:12]([CH:6]1[C:5]2[C:10](=[CH:11][C:2]([NH:1][CH:2]3[CH2:11][CH2:10][CH2:5][CH2:4][CH2:3]3)=[CH:3][CH:4]=2)[C:8](=[O:9])[O:7]1)[CH2:13][CH2:14][CH3:15]

Participants

5

Reactant 1

HCID 98777066-Amino-3-butyl-phthalide

Product 1

HCID 23439119HCID 23439119, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 7967CyclohexanoneSolvent

Procedure

Analogously to the method described in Example 14, 4.1 g (20.0 mmol) of compound obtained in Example 4 in 5 ml of cyclohexanone and 150 ml of 95% ethanol are added to 10% Pd—C catalyst and hydrogenated to give the title compound.

Sources & evidence

ORD record
ord-9e02888d32654489ae6119f4646bc8a0
Source dataset
uspto-grants-2004_02
Patent number
US06689808B2

Reaction notes

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