HuagongsheHuagongshe Chemistry Print Report · For research reference only
Salicylaldehyde → 3-(2-Hydroxybenzylidene)-6-thiophen-2-yl-1,3-dihydroindol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Salicylaldehyde | HCID 6998 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 6-Thiophen-2-yl-1,3-dihydro-indol-2-one | HCID 21906989 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(2-Hydroxybenzylidene)-6-thiophen-2-yl-1,3-dihydroindol-2-one | HCID 53890169 | 50.1% |
Reaction Steps
A mixture of 6-thiophen-2-yl-1,3-dihydroindol-2-one (100 mg, 0.5 mmol), 2-hydroxybenzaldehyde (60 mg, 0.5 mmol) and piperidine (0.23 mL) in ethanol (4 mL) was stirred at reflux overnight. The reaction mixture was concentrated and column chromatographed (eluant—isopropanol/dichloromethane) to give 80 mg (50%) of 3-(2-hydroxybenzylidene)-6-thiophen-2-yl-1,3-dihydroindol-2-one as a yellow-orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06689806B1 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-2e57120d44044a998c0369582491fb23 |
| Source note | uspto-grants-2004_02 |