HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-Oxoindolin-6-yl)acetamide → N-{3-[3-cyclohexyl-4-(2-morpholin-4-ylethoxy)-benzyl]-2-oxo-2,3-dihydro-1H-indol-6-yl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-Oxoindolin-6-yl)acetamide | HCID 2749839 | — |
| Reactant | N-{3-[3-Cyclohexyl-4-(2-morpholin-4-ylethoxy)-benzylidene]-2-oxo-2,3-dihydro-1H-indol-6-yl}-acetamide | HCID 53981954 | — |
| Reactant | 3-Cyclohexyl-4-morpholinoethoxybenzaldehyde | HCID 54226174 | — |
| Product | N-{3-[3-cyclohexyl-4-(2-morpholin-4-ylethoxy)-benzyl]-2-oxo-2,3-dihydro-1H-indol-6-yl}-acetamide | HCID 23439075 | 80% |
Reaction Steps
6-Acetamido-2-oxindole was condensed with 3-cyclohexyl-4-morpholinoethoxybenzaldehyde using method B to give a mixture of isomers of N-{3-[3-cyclohexyl-4-(2-morpholin-4-ylethoxy)-benzylidene]-2-oxo-2,3-dihydro-1H-indol-6-yl}-acetamide as a mustard yellow solid which was reduced using method E to give 0.04 g (80%) of N-{3-[3-cyclohexyl-4-(2-morpholin-4-ylethoxy)-benzyl]-2-oxo-2,3-dihydro-1H-indol-6-yl}-acetamide as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06689806B1 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-b1f3e734eed041b89ad77e6f2a0758b7 |
| Source note | uspto-grants-2004_02 |