Oxindole → 3-(3,5-Diisopropyl-4-methoxybenzylidene)-1,3-dihydroindol-2-one

HRID 2120210Notes

Reaction equation

HRID 2120210 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=[O:10].[CH:11]([C:14]1[CH:15]=[C:16]([CH:19]=[C:20]([CH:24]([CH3:26])[CH3:25])[C:21]=1[O:22][CH3:23])[CH:17]=O)([CH3:13])[CH3:12]>>[CH:24]([C:20]1[CH:19]=[C:16]([CH:15]=[C:14]([CH:11]([CH3:13])[CH3:12])[C:21]=1[O:22][CH3:23])[CH:17]=[C:3]1[C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[NH:1][C:2]1=[O:10])([CH3:25])[CH3:26]

Participants

3

Reactant 2

HCID 321710OxindoleHCID 105850253,5-Diisopropyl-4-methoxybenzaldehyde

Product 1

HCID 543582963-(3,5-Diisopropyl-4-methoxybenzylidene)-1,3-dihydroindol-2-one

Procedure

2-Oxindole was condensed with 3,5-diisopropyl-4-methoxybenzaldehyde using method B to give 3-(3,5-diisopropyl-4-methoxy-benzylidene)-1,3-dihydro-indol-2-one as a yellow-orange solid which was reduced using method E to give 2 g (100%) of 3-(3,5-diisopropyl-4-methoxybenzyl)-1,3-dihydroindol-2-one as a white solid.

Sources & evidence

ORD record
ord-7e051d0e6dc64bc897008c41afac218b
Source dataset
uspto-grants-2004_02
Patent number
US06689806B1

Reaction notes

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