Indole-5-carboxaldehyde → HCID 53889260, compound

HRID 2120214Notes

Reaction equation

HRID 2120214 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][C:5](=[O:11])[NH:6]2.[NH:12]1[C:20]2[C:15](=[CH:16][C:17]([CH:21]=O)=[CH:18][CH:19]=2)[CH:14]=[CH:13]1>>[NH:12]1[C:20]2[C:15](=[CH:16][C:17]([CH:21]=[C:4]3[C:3]4[C:7](=[CH:8][CH:9]=[CH:10][C:2]=4[CH3:1])[NH:6][C:5]3=[O:11])=[CH:18][CH:19]=2)[CH:14]=[CH:13]1

Participants

3

Reactant 2

HCID 589040Indole-5-carboxaldehydeHCID 125793824-Methyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 53889260HCID 53889260, compound

Procedure

4-Methyl-2-oxindole was condensed with 1H-indole-5-carbaldehyde using method B to give 3-(1H-indol-5-ylmethylene)-4-methyl-1,3-dihydroindol-2-one as a white solid which was reduced using method C to give 20 mg (40%) of 3-(1H-indol-5-ylmethyl)-4-methyl-1,3-dihydroindol-2-one.

Sources & evidence

ORD record
ord-64f05c3e182943bba86d885d582eedbf
Source dataset
uspto-grants-2004_02
Patent number
US06689806B1

Reaction notes

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