3-Fluorosalicylaldehyde → HCID 54139969, compound

HRID 2120222Notes

Reaction equation

HRID 2120222 reaction equation
[C:1]1([C:7]2[CH:15]=[C:14]3[C:10]([CH2:11][C:12](=[O:16])[NH:13]3)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:17][C:18]1[C:19]([OH:26])=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH:21]=O>>[F:17][C:18]1[C:19]([OH:26])=[C:20]([CH:23]=[CH:24][CH:25]=1)[CH:21]=[C:11]1[C:10]2[C:14](=[CH:15][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:8][CH:9]=2)[NH:13][C:12]1=[O:16]

Participants

3

Reactant 2

HCID 5877883-FluorosalicylaldehydeHCID 105363846-Phenyl-1,3-dihydro-indol-2-one

Product 1

HCID 54139969HCID 54139969, compoundYield 53%

Procedure

6-phenyl-2-oxindole (50 mg, 0.3 mmol) was condensed with 3-fluoro-2-hydroxybenzaldehyde (50 mg, 0.36 mmol) using method B to give 52 mg (53%) of 3-(3-fluoro-2-hydroxybenzylidene)-6-phenyl-1,3-dihydroindol-2-one as a yellow/orange solid.

Sources & evidence

ORD record
ord-3d82f1ff833540a58f7c41f73a387a2c
Source dataset
uspto-grants-2004_02
Patent number
US06689806B1

Reaction notes

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