2-Hydroxy-4-Methoxybenzaldehyde → HCID 54470056, compound

HRID 2120223Notes

Reaction equation

HRID 2120223 reaction equation
[C:1]1([C:7]2[CH:15]=[C:14]3[C:10]([CH2:11][C:12](=[O:16])[NH:13]3)=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:17][C:18]1[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[CH:22][C:19]=1[CH:20]=O>>[OH:17][C:18]1[CH:25]=[C:24]([O:26][CH3:27])[CH:23]=[CH:22][C:19]=1[CH:20]=[C:11]1[C:10]2[C:14](=[CH:15][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[CH:8][CH:9]=2)[NH:13][C:12]1=[O:16]

Participants

3

Reactant 2

HCID 696002-Hydroxy-4-MethoxybenzaldehydeHCID 105363846-Phenyl-1,3-dihydro-indol-2-one

Product 1

HCID 54470056HCID 54470056, compoundYield 68%

Procedure

6-Phenyl-2-oxindole (50 mg, 0.3 mmol) was condensed with 2-hydroxy-4-methoxybenzaldehyde (50 mg, 0.33 mmol) using method B to give 70 mg (68%) of 3-(2-hydroxy-4-methoxybenzylidene)-6-phenyl-1,3-dihydroindol-2-one as a yellow/orange solid.

Sources & evidence

ORD record
ord-d6e855485c02422b88d5005c45eaac44
Source dataset
uspto-grants-2004_02
Patent number
US06689806B1

Reaction notes

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