6-Methyl-2-pyridinecarboxaldehyde → HCID 54057084, compound

HRID 2120225Notes

Reaction equation

HRID 2120225 reaction equation
[OH:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][C:7](=[O:13])[NH:8]2.[CH3:14][C:15]1[N:20]=[C:19]([CH:21]=O)[CH:18]=[CH:17][CH:16]=1>>[OH:1][CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[CH:21][C:19]1[CH:18]=[CH:17][CH:16]=[C:15]([CH3:14])[N:20]=1)[C:7](=[O:13])[NH:8]2

Participants

3

Reactant 2

HCID 707376-Methyl-2-pyridinecarboxaldehydeHCID 109430044-(2-Hydroxyethyl)indolin-2-one

Product 1

HCID 54057084HCID 54057084, compound

Procedure

4-(2-Hydroxyethyl)-1,3-dihydroindol-2-one (89 mg, 0.5 mmol) was condensed with 6-methyl-2-pyridinecarbaldehyde (61 mg, 0.5 mmol) using method B to give 4-(2-hydroxyethyl)-3-(6-methylpyridin-2-ylmethylene)-1,3-dihydroindol-2-one as a yellow solid.

Sources & evidence

ORD record
ord-419940c94a6b47fd9f2e67d1768e598d
Source dataset
uspto-grants-2004_02
Patent number
US06689806B1

Reaction notes

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