Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 6-Methyl-2-pyridinecarboxaldehyde | HCID 70737 | — |
| Reactant | 4-(2-Hydroxyethyl)indolin-2-one | HCID 10943004 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54057084 | HCID 54057084 | — |
Reaction Steps
A mixture of 4-(2-hydroxy-ethyl)-1,3-dihydro-indol-2-one (89 mg, 0.5 mmol), 6-methyl-2-pyridine-carbaldehyde (61 mg, 0.5 mmol) and piperidine (0.1 mL) in 1.0 mL of ethanol was heated at 100° C. for 1 hour and cooled to room temperature. The precipitate was filtered and recrystallized from ethyl acetate and hexanes to give 4-(2-hydroxy-ethyl)-3-(6-methyl-pyridin-2-ylmethylene)-1,3-dihydro-indol-2-one as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06689806B1 |
|---|
| Source dataset | uspto-grants-2004_02 |
|---|
| ORD ID | ord-a6bf925c3bb34a9fb6ba904c1282653a |
|---|
| Source note | uspto-grants-2004_02 |
|---|
