4-Mercaptobenzoic acid → HCID 69882217, 화합물

HRID 2120374노트

반응식

HRID 2120374 반응식
[Cl:1][C:2]1[C:7](F)=[C:6]([S:9]([C:12]2[CH:17]=[CH:16][C:15]([C:18](=[O:22])[N:19]([CH3:21])[CH3:20])=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH:5]=[CH:4][C:3]=1[NH:23][C:24](=[O:32])[C@:25]([OH:31])([CH3:30])[C:26]([F:29])([F:28])[F:27].[SH:33][C:34]1[CH:42]=[CH:41][C:37]([C:38]([OH:40])=[O:39])=[CH:36][CH:35]=1>>[Cl:1][C:2]1[C:7]([S:33][C:34]2[CH:42]=[CH:41][C:37]([C:38]([OH:40])=[O:39])=[CH:36][CH:35]=2)=[C:6]([S:9]([C:12]2[CH:13]=[CH:14][C:15]([C:18](=[O:22])[N:19]([CH3:21])[CH3:20])=[CH:16][CH:17]=2)(=[O:11])=[O:10])[CH:5]=[CH:4][C:3]=1[NH:23][C:24](=[O:32])[C@:25]([OH:31])([CH3:30])[C:26]([F:27])([F:28])[F:29]

참가 물질

3

반응물 2

HCID 957384-Mercaptobenzoic acidHCID 69824386HCID 69824386, 화합물

생성물 1

HCID 69882217HCID 69882217, 화합물

실험 절차

(R)-N-{2-Chloro-3-fluoro-4-[4-(N,N-dimethylcarbamoyl)phenylsulphonyl]phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide (Example 18) was treated with 4-mercaptobenzoic acid according to the procedure of Example 50 to yield the title compound as a white solid.(0.39 g, 25%). NMR: 1.60 (s, 3H), 2.90 (s, 3H), 3.00 (s, 3H), 7.55-7.65 (m, 4H); 7.90-7.95 (m, 4H), 8.05 (s, 1H), 8.55 (d, 1H), 8.65 (d, 1H), 9.95 (s, 1H); 10.60 (s, 1H); m/z: 629.

출처 및 근거

ORD 기록
ord-f4b16bcee33c43f09d705518af0c071a
출처 데이터셋
uspto-grants-2004_02
특허 번호
US06689909B1

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