Ethanol → HCID 23439417, compound

Participants

Reaction Steps

2-Chloro-3-fluoro-4-[4-(N-ethylcarbamoyl)phenylsulphanyl]nitrobenzene (Method 82; 360 mg, 1.02 mmol), iron powder (617 mg), EtOH (0.68 ml), water (0.28 ml) and 1 drop of conc. HCl were heated at 75° C. with stirring for 45 minutes. The mixture was allowed to cool to room temp and then made basic using saturated sodium bicarbonate solution. EtOAc was added and the solution was poured onto a Chem Elut column and eluted with EtOAc to yield the title compound (260 mg) as a pale yellow sticky solid. NMR: 1.1 (t, 3H), 3.2 (q, 2H), 6.1 (s, 1H), 7.0 (q, 2H), 7.2 (q, 1H), 7.7 (t, 2H), 8.3 (d, 1H).

Provenance & Evidence