1,2-Benzenedicarboxylic acid, 4-nitro- → 4-Aminophthalic acid

HRID 2120426Notes

Reaction equation

HRID 2120426 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9])([O-])=O>C(O)C>[NH2:1][C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[C:7](=[CH:11][CH:12]=1)[C:8]([OH:10])=[O:9]

Participants

3

Reactant 1

HCID 691211,2-Benzenedicarboxylic acid, 4-nitro-

Product 1

HCID 729124-Aminophthalic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1 g (4.73 mmol) of 4-nitrophthalic acid is dissolved in 10 ml of anhydrous ethanol. The solution is stirred at room temperature and degassed under argon. 50 mg of 5% palladium/carbon are added all at once and hydrogen is bubbled through the solution. After 3 hours, the solution is filtered on celite and then evaporated.

Workup

  1. customdegassed under argon
  2. addition50 mg of 5% palladium/carbon are added all at once and hydrogen
  3. customis bubbled through the solution
  4. filtrationthe solution is filtered on celite
  5. customevaporated

Sources & evidence

ORD record
ord-aa373232ad7446578dd043244734d691
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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