Water → HCID 57062830, compound

Participants

Reaction Steps

350 mg (0.76 mmol) of 5-{[3-(3,4-bis-carboxymethylbenzyloxy)phenyl]ethylamino}-5-oxo-2-methylpentan-2-ol are dissolved in 10 ml of anhydrous THF and then 120 mg of lithium aluminium hydride (3.1 mmol) are added in two equal portions. After heating under reflux for 4 hours, the reaction medium is cooled and then sequentially treated with 120 l of water, 120 l of a 15% NaOH solution and then 360 l of water. After stirring for 1 hour, the reaction medium is filtered, concentrated and then purified by chromatography on a silica gel. A colourless oil is obtained (m=280 mg; Y=95%).

Provenance & Evidence