HCID 86759347, compound → HCID 69685852, compound

HRID 2120490Notes

Reaction equation

HRID 2120490 reaction equation
[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][C:28]=1[CH2:29][OH:30])[CH2:6][O:7][C:8]1[CH:9]=[C:10](/[C:14](/[CH2:23][CH2:24][CH3:25])=[CH:15]\[CH2:16][CH2:17]C(OCC)=O)[CH:11]=[CH:12][CH:13]=1.C[Mg]Br>>[OH:1][CH2:2][C:3]1[CH:4]=[C:5]([CH:26]=[CH:27][C:28]=1[CH2:29][OH:30])[CH2:6][O:7][C:8]1[CH:9]=[C:10](/[C:14](/[CH2:23][CH2:24][CH3:25])=[CH:15]\[CH2:16][CH2:17][C:8]([CH3:9])([OH:7])[CH3:13])[CH:11]=[CH:12][CH:13]=1

Participants

3

Reactant 2

HCID 86759347HCID 86759347, compoundHCID 178418573HCID 178418573, compound

Product 1

HCID 69685852HCID 69685852, compound

Procedure

In a manner similar to Example 84(c), by reacting 1 g (1.6 mmol) of ethyl (Z)-5-[3-(3,4-bis-hydroxymethylbenzyloxy)phenyl]oct-4-enoate (prepared in a manner similar to Examples 84(a-b)) with 5.4 ml (16 mmol) of a 3.0M solution of methylmagnesium bromide, a colourless oil is obtained (m=516 mg; Y=81%).

Workup

  1. customa colourless oil is obtained (m=516 mg; Y=81%)

Sources & evidence

ORD record
ord-bd5b1745281e4f468785bb83adda5469
Source dataset
uspto-grants-2004_02
Patent number
US06689922B1

Reaction notes

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