Flurbiprofen → HCID 131723197, compound

HRID 2120498Notes

Reaction equation

HRID 2120498 reaction equation
Cl.[NH2:2][C@H:3]([CH3:15])[C:4]([NH:6][O:7]CC1C=CC=CC=1)=[O:5].[F:16][C:17]1[CH:22]=[C:21]([CH:23]([CH3:27])[C:24]([OH:26])=O)[CH:20]=[CH:19][C:18]=1[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[F:16][C:17]1[CH:22]=[C:21]([CH:23]([CH3:27])[C:24]([NH:2][C@H:3]([CH3:15])[C:4]([NH:6][OH:7])=[O:5])=[O:26])[CH:20]=[CH:19][C:18]=1[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 3394FlurbiprofenHCID 88035642HCID 88035642, compound

Product 1

HCID 131723197HCID 131723197, compound

Procedure

This compound was synthesized by coupling 2-amino-N-benzyloxy-(R)-propionamide HCl salt 42b with (R/S)-2-fluoro-α-methyl-4-biphenylacetic acid (flurbiprofen, Sigma) followed by hydrogenation using the procedures as described in Example 42. MS (ESI): (M−H)−=329.0.

Workup

  1. customThis compound was synthesized

Sources & evidence

ORD record
ord-59dc301fc8c2479fbb69da9dc380094f
Source dataset
uspto-grants-2004_02
Patent number
US06689771B2

Reaction notes

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