HuagongsheHuagongshe Chemistry Print Report · For research reference only
Toluene → 3-(4-Bromophenyl)propan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Toluene | HCID 1140 | — |
| Reactant | 3-(4-bromophenyl)prop-2-yn-1-ol | HCID 4048181 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 3-(4-Bromophenyl)propan-1-ol | HCID 10560614 | 81.1% |
Reaction Steps
To a solution under inert gas of 36.4 g of 3-(4-bromophenyl)-2-propynol (stage A) in 200 ml of ethanol at 5% of toluene, is added 200 ml of toluene, 7.9 g of Wilkinson's reagent and hydrogen at 1900 mbar for 5 hours. It is evaporated at reduced pressure until the obtainment of 45.9 g of raw product that is purified by chromatography on silica by eluting with the compound CH2Cl2/AcOEt 95/5. 30.1 g of expected product is obtained. Rf (CH2Cl2/AcOEt 95/5): 0.28 IR (CHCl3)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693090B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-f73728e968044fea9bd017ebb80e238d |
| Source note | uspto-grants-2004_02 |