Sodium Methoxide → Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate

HRID 2120569Notes

Reaction equation

HRID 2120569 reaction equation
[CH3:1][O-:2].[Na+].[C:4]([C:6]1[C:14]2[C:9](=[N:10][CH:11]=[CH:12][CH:13]=2)[N:8]([CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[F:22])[N:7]=1)#[N:5]>CO>[F:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[CH2:15][N:8]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:14]2[C:6]([C:4](=[NH:5])[O:2][CH3:1])=[N:7]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 114025001-((2-Fluorophenyl)methyl)pyrazolo(3,4-b)pyridine-3-carbonitrile

Product 1

HCID 11243078Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

30.37 g (562 mmol) of sodium methoxide are dissolved in 1.5 l of methanol and 36.45 g (144.5 mmol) of 3-cyano-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine (from Example 3D) are added. The mixture is stirred at room temperature for 2 hours and the solution obtained is employed directly for the next step.

Workup

  1. customthe solution obtained

Sources & evidence

ORD record
ord-e70719b6157547aaae26c0bb4826adfb
Source dataset
uspto-grants-2004_02
Patent number
US06693102B2

Reaction notes

Loading…