HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate | HCID 11243078 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide | HCID 11403986 | — |
Reaction Steps
The solution of methyl (2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidate obtained from Example 3E) in methanol is treated with 33.76 g (32.19 ml, 562 mmol) of glacial acetic acid and 9.28 g (173 mmol) of ammonium chloride and stirred overnight under reflux. The solvent is evaporated in vacuo, the residue is triturated well with acetone and the deposited solid is filtered off with suction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693102B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-9352ae7460b740d7a8182ced24f69f89 |
| Source note | uspto-grants-2004_02 |