HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl (R)-(+)-2-isocyanato-3-phenylpropionate → (R)-2-(4-Phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl (R)-(+)-2-isocyanato-3-phenylpropionate | HCID 6558897 | — |
| Reactant | (4-(Phenoxymethyl)phenyl)methanol | HCID 11333367 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | (R)-2-(4-Phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester | HCID 12990904 | 95.4% |
Reaction Steps
4-Phenoxymethylphenylmethanol 4 (0.857 g, 4.0 mmol), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.026 g, 5.0 mmol) and 4-dimethylaminopyridine (DMAP) (10 mg) were combined, heated until molten, and stirred for 20 min. Upon cooling, the residue was purified by chromatography to give about 1.6 g of (R)-2-(4-phenoxymethyl-benzyloxycarbonylamino)-3-phenyl-propionic acid methyl ester 6.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693098B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-7c09ed7cd7c24225b9181ced94dee108 |
| Source note | uspto-grants-2004_02 |