HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2120577Generated: November 1, 2026
4-Phenethyloxybenzoic Acid Methyl Ester → (4-Phenethyloxyphenyl)methanol
https://huagongshe.com/reaction/2120577
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Phenethyloxybenzoic Acid Methyl Ester | HCID 12063834 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | (4-Phenethyloxyphenyl)methanol | HCID 12990905 | 98.2% |
Reaction Steps
4-Phenethyloxybenzoic acid methyl ester 10 (7.66 g, 29.89 mmol) was dissolved in diethyl ether and chilled to 0° C. LiAlH4 was slowly added and allowed to stir at 0° C. for 3 hours. The mixture was quenched with H2O. After addition of 3N NaOH the mixture was allowed to stir for 30 min. The mixture was then acidified with 4.5N HCl, extracted, dried, and concentrated in vacuo to give about 6.7 g of a crystalline (4-phenethyloxyphenyl)methanol 11.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06693098B2 |
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| Source dataset | uspto-grants-2004_02 |
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| ORD ID | ord-bf2627b18a2c44cca4d4d9f49ae58ec2 |
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| Source note | uspto-grants-2004_02 |
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