HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl (R)-(+)-2-isocyanato-3-phenylpropionate → (R)-2-(4-Phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl (R)-(+)-2-isocyanato-3-phenylpropionate | HCID 6558897 | — |
| Reactant | (4-Phenethyloxyphenyl)methanol | HCID 12990905 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Product | (R)-2-(4-Phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic Acid Methyl Ester | HCID 12990906 | 96.9% |
Reaction Steps
(4-Phenethyloxyphenyl)methanol 11(1.141 g, 5.0 mmol), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.036 g, 5.0 mmol) and DMAP (10 mg) were combined and heated until molten and stirred for 20 min. Upon cooling the residue was purified by chromatography to give about 2.1 g of (R)-2-(4-phenethyloxybenzyloxycarbonylamino)-3-phenyl-propionic acid methyl ester 12.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693098B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-ab890d7138c04afca959e42164198411 |
| Source note | uspto-grants-2004_02 |