HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2120582Generated: November 1, 2026
Triethylamine → (R)-2-(5-Phenyl-benzofuran-2-ylmethoxycarbonylamino)-3-phenylpropionic Acid Methyl Ester
https://huagongshe.com/reaction/2120582
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl (R)-(+)-2-isocyanato-3-phenylpropionate | HCID 6558897 | — |
| Reactant | 2-Hydroxymethyl-5-phenyl-benzofuran | HCID 11379094 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (R)-2-(5-Phenyl-benzofuran-2-ylmethoxycarbonylamino)-3-phenylpropionic Acid Methyl Ester | HCID 12990909 | 63.7% |
Reaction Steps
A mixture of 2-hydroxmethyl-5-phenyl-benzofuran 17 (1.20 g, 5.85 mmole), (R)-2-isocyanato-3-phenyl-propionic acid methyl ester 5 (1.2 g, 5.9 mmole), triethylamine (1.7 ml), and THF (30 ml) was heated to 50° C. under a nitrogen atmosphere for 6 hrs. The solvent was removed under reduced pressure and the residue was purified by chromatography giving about 1.6 g of (R)-2-(phenyl-benzofuran-2-ylmethoxycarbonylamino)-3-phenyl-propionic acid methyl ester 18, mp. 85-86° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06693098B2 |
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| Source dataset | uspto-grants-2004_02 |
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| ORD ID | ord-5a06e05afe844a6e95e06c3f87c03784 |
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| Source note | uspto-grants-2004_02 |
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