Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → Methyl 2-phenylbenzofuran-5-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Phenylacetylene | HCID 10821 | — |
| 반응물 | 1,1,3,3-Tetramethylguanidine | HCID 66460 | — |
| 반응물 | Methyl 4-hydroxy-3-iodobenzoate | HCID 11346465 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Methyl 2-phenylbenzofuran-5-carboxylate | HCID 66865443 | 99.1% |
반응 단계
A mixture of methyl 3-iodo-4-hydroxybenzoate 26 (1 g, 3.6 mmol), phenylacetylene (2 ml, 18 mmol), tetramethylguanidine (4.5 ml, 36 mmol), copper(I)iodide (34 mg, 1.8 mmol), bis(triphenylphosphine)palladium (II)chloride (130 mg, 1.8 mmol) and DMF (20 ml) was stirred at room temperature overnight. The reaction mixture was poured into water, extracted, washed and dried. After evaporation of the solvent, the residue was purified by chromatography to give about 0.9 g of 2-phenyl-benzofuran-5-carboxylic acid methyl ester 27.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06693098B2 |
| 출처 데이터셋 | uspto-grants-2004_02 |
| ORD ID | ord-53d73c4db76444b18bb7af91de18f0dc |
| 출처 메모 | uspto-grants-2004_02 |