HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azobisisobutyronitrile → 2-Bromomethyl-5-phenyl-benzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Benzoxazole, 2-methyl-5-phenyl- | HCID 112786 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 2-Bromomethyl-5-phenyl-benzoxazole | HCID 15133754 | 32.3% |
Reaction Steps
2-Methyl-5-phenyl-benzoxazole 48 (1.05 g, 5.0 mmol), N-bromosuccinimide (89 mg, 5.0 mmol) and azodiisobutyronitrile (AIBN) (41 mg, 0.25 mmol) in 10 ml of CCl4 was heated to reflux. After 5 hrs an additional 50 mg AIBN were added and the mixture was refluxed overnight. The mixture was diluted, washed with water, dried and concentrated. The crude product was chromatographed to give about 465 mg 2-bromomethyl-5-phenyl-benzoxazole 49.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693098B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-47ee6321853341c1bf74fe7372c3bb09 |
| Source note | uspto-grants-2004_02 |