1,4-Dioxane hydrochloride → HCID 23435534, compound

HRID 2120654Notes

Reaction equation

HRID 2120654 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([I:18])=[N:13][C:14]([I:17])=[CH:15][CH:16]=1)(C)(C)C.Cl.O1CCOCC1>ClCCl>[I:18][C:12]1[C:11]([O:10][CH2:9][CH2:8][NH2:7])=[CH:16][CH:15]=[C:14]([I:17])[N:13]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 20622498HCID 20622498, compound

Product 1

HCID 23435534HCID 23435534, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 4-2 (2.18 g, 4.45 mmol) in dichloromethane (5.0 mL) at room temperature under Ar was added 4.0 M HCl-dioxane solution (25 mL). A white precipitate formed immediately. After two hours the reaction was concentrated and dried to yield a white solid.

Workup

  1. customA white precipitate formed immediately
  2. concentrationAfter two hours the reaction was concentrated
  3. customdried
  4. customto yield a white solid

Sources & evidence

ORD record
ord-1236036810cd458e9fdb0428d0941c36
Source dataset
uspto-grants-2004_02
Patent number
US06693101B2

Reaction notes

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