HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2120682Generated: October 27, 2026
Tetrahydrofuran → 9-Benzyloxy-1-(2-methyl-pyrimidin-5-yl)-non-1-en-4-one
https://huagongshe.com/reaction/2120682
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Methylpyrimidine-5-carbaldehyde | HCID 3160970 | — |
| Reactant | (7-Benzyloxy-2-oxo-heptyl)-phosphonic acid dimethyl ester | HCID 58765522 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 9-Benzyloxy-1-(2-methyl-pyrimidin-5-yl)-non-1-en-4-one | HCID 69666598 | 100% |
Reaction Steps
A mixture of 11-2 (4.4 g, 13.8 mmol), 2-methyl-pyrimidine-5-carbaldehyde (1.5 g, 12.5 mmol; for preparation, see J. Heterocyclic Chem., 28, 1281 (1991)) potassium carbonate (3.1 g, 25 mmol) and THF (200 mL) was heated at 60° C. for 3 hours. Following cooling, the mixture was diluted with ethyl acetate, washed with sat. NaHCO3 and brine, and dried over magnesium sulfate. Evaporation of the solvents gave 4.0 g (100%) of 11-3 as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06693101B2 |
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| Source dataset | uspto-grants-2004_02 |
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| ORD ID | ord-3b35373817a640278191f1599c17c0c2 |
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| Source note | uspto-grants-2004_02 |
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