Water → 4-(4-Aminophenyl)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

Participants

Reaction Steps

In a similar manner to Step 1 of Example 152, 4-trifluoromethanesulfonyloxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (150 mg, 0.250 mmol) was dissolved in dimethoxyethane (10.5 mL), and the solution was treated with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaboran-2-yl)aniline (110 mg, 0.500 mmol), [bis(diphenylphosphino)ferrocene]dichloropalladium (25 mg, 0.030 mmol), potassium carbonate (173 mg, 1.25 mmol) and water (0.090 mL), followed by purification by preparative thin-layer chromatography (chloroform/methanol=5/1) to obtain 4-(4-aminophenyl)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (76.5 mg, yield 57%).

Provenance & Evidence