Maleic Acid → Prasugrel (Maleic acid)

Participants

Reaction Conditions

Reaction Steps

To a solution of maleic acid (4.43 g) in acetone (60 ml) was added 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (15.0 g) obtained in Reference example 1, then the mixture was stirred at room temperature (25° C.) for 2 hours. The resulting crystals were separated by filtration and washed with a small amount of acetone and then dried at 50° C. under reduced pressure for 4 hours to give the title compound as white crystals (17.1 g, yield 92%)

Provenance & Evidence