Maleic Acid → Prasugrel (Maleic acid)

Participants

Reaction Steps

To a solution of maleic acid (932 g) in acetone (15 L) heated to 40° C. was added 2-acetoxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine (3000 g) obtained in Reference example 1. The mixture was stirred at room temperature for 2 hours. The resulting crystals were separated by filtration and washed with acetone (4 L) and then dried at 60° C. under reduced pressure for 8 hours to give the title compound as white crystals (3538 g, yield 90%)

Provenance & Evidence