HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2120760Generated: October 27, 2026
Triethylamine → 3-Fluoro-N-(5-methoxy-8-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-benzamide
https://huagongshe.com/reaction/2120760
Participants
| Role | Name | HCID | Charge |
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| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Fluorobenzoyl chloride | HCID 74376 | — |
| Reactant | 5-Methoxy-8-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl-amine | HCID 23435881 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Fluoro-N-(5-methoxy-8-phenyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-benzamide | HCID 23435878 | — |
Reaction Steps
A mixture of 15 mg (0.062 mmol) 5-methoxy-8-phenyl-[1,2,4]triazolo[1,5-a]-pyridin-2-yl-amine, 11 mg (0.068 mmol) 3-fluorophenyl carboxylic acid chloride, and 31.5 μl (0.312 mmol) NEt3 in 1 ml dioxane was heated to 90° C. for 16 h. The mixture was purified by preparative HPLC on reversed phase eluting with an acetonitrile/water gradient. Evaporation yielded the title compound. MS m/e (%): 281.7 ((M+CH3CN)+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06693116B2 |
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| Source dataset | uspto-grants-2004_02 |
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| ORD ID | ord-fec5e731dd0f4763b31afdf04ea3321b |
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| Source note | uspto-grants-2004_02 |
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