5-Methyl-3-phenylisoxazole-4-carboxylic acid → 5-Methyl-3-phenylisoxazole-4-carbonyl chloride

HRID 2120857Notes

Reaction equation

HRID 2120857 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([OH:15])=O.O=S(Cl)[Cl:18]>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[C:13]([Cl:18])=[O:15]

Participants

3

Reactant 2

HCID 143435-Methyl-3-phenylisoxazole-4-carboxylic acidHCID 24386Thionyl Chloride

Product 1

HCID 856245-Methyl-3-phenylisoxazole-4-carbonyl chloride

Procedure

5-Methyl-3-phenyl-isoxazole-4-carboxylic acid (0.54 g, 2.56 mmol) was treated with SOCl2 (2 mL) at 70° C. for 1 hr. Concentration in vacuum gave a yellow oil which was used without purification.

Workup

  1. concentrationConcentration in vacuum
  2. customgave a yellow oil which
  3. customwas used without purification

Sources & evidence

ORD record
ord-d44e0f02d5454ede8534eb72d18c1de9
Source dataset
uspto-grants-2004_02
Patent number
US06693108B2

Reaction notes

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