HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 4-(4-(2-Bromo-pyridin-4-yl)-3-phenyl-isoxazol-5-ylmethyl)-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-4-(5-bromomethyl-3-phenyl-isoxazol-4-yl)-pyridine | HCID 23435644 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | 4-(4-(2-Bromo-pyridin-4-yl)-3-phenyl-isoxazol-5-ylmethyl)-morpholine | HCID 23435645 | 94.3% |
Reaction Steps
A stirred solution of the above Compound 18a (484 mg, 1.22 mmol), morpholine (0.45 mL, 5.1 mmol) and K2CO3 (340 mg, 2.45 mmol) in anhydrous DMF (2 mL) was warmed to 40° C. for 18 h. The solution was poured into brine (10 ml), extracted with CH2Cl2 (3×15 mL), dried (MgSO4), and filtered. Flash chromatography (SiO2, 50% EtOAc-hexanes) provided the title compound (461 mg, 1.15 mmol, 94%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06693108B2 |
| Source dataset | uspto-grants-2004_02 |
| ORD ID | ord-4076d29aaff544d8a92c0fd47cc264e1 |
| Source note | uspto-grants-2004_02 |