Acetic Acid → HCID 69842085, compound

HRID 2120956Notes

Reaction equation

HRID 2120956 reaction equation
Cl.[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:15][C:14]3([CH2:20][CH2:19][N:18]([CH2:21][C:22]([O:24]CC)=[O:23])[CH2:17][CH2:16]3)[O:13][N:12]=2)=[CH:7][CH:6]=1.[OH-].[Na+].C(O)(=O)C.O>C(O)C>[NH2:2][N:3]=[CH:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH2:15][C:14]3([CH2:16][CH2:17][N:18]([CH2:21][C:22]([OH:24])=[O:23])[CH2:19][CH2:20]3)[O:13][N:12]=2)=[CH:7][CH:6]=1

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 86584287HCID 86584287, compound

Product 1

HCID 69842085HCID 69842085, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

0.12 g (0.315 mmol) of the ester from Example 5 were dissolved in 2 ml ethanol, and after addition of 0.4 ml 2 N aqueous sodium hydroxide solution the mixture was stirred overnight at room temperature. It was adjusted to pH 4 with diluted acetic acid. The solvent was removed from the clear solution under reduced pressure to leave a brown oil, which solidified by stirring with a mixture of ethanol and water. It was filtered, stirred in a small amount of hot ethanol, filtered again, and dried in vacuo.

Workup

  1. customThe solvent was removed from the clear solution under reduced pressure
  2. customto leave a brown oil, which
  3. filtrationIt was filtered
  4. stirringstirred in a small amount of hot ethanol
  5. filtrationfiltered again
  6. customdried in vacuo

Sources & evidence

ORD record
ord-c3d2c43997e04ae7a7e2eb494f4213f6
Source dataset
uspto-grants-2004_02
Patent number
US06693109B2

Reaction notes

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