Dimethylformamide → HCID 9866320, compound

Participants

Reaction Steps

A solution of [(2R)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl 4-methylbenzenesulfonate (0.192 g, 0.499 mmol), 3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (0.119 g, 0.601 mmol) and K2CO3 (0.104 g, 0.753 mmol) in (1:1) THF:DMF (1.4 mL) was heated to 80-83° C. for 10 h. After this time, H2O (3 mL) was added and the suspension was filtered. The filtered solid was washed with CH3OH (2×3 mL), Et2O (2×5 mL) and air-dried to give 0.148 g (72%) of the title compound as a tan solid.

Provenance & Evidence