methyl (2S)-2-amino-4-(methylsulfanyl)butanoate → 4-Fluoro-2-phenylbenzoyl Methionine Methyl Ester
Reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:3]=1.[CH3:17][O:18][C:19](=[O:26])[C@H:20]([CH2:22][CH2:23][S:24][CH3:25])[NH2:21]>>[CH3:17][O:18][C:19](=[O:26])[C@H:20]([CH2:22][CH2:23][S:24][CH3:25])[NH:21][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([F:1])=[CH:3][C:4]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1Participants
3
Procedure
The resultant product from Example 13B is coupled to methionine methyl ester according to the procedure of Example 1C to give the tide compound.
Workup
- customto give the tide compound
Sources & evidence
- ORD record
- ord-e440def421314c6e856863b454be23e0
- Source dataset
- uspto-grants-2004_02
- Patent number
- US06693123B2
Reaction notes
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