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2-Aminopyridine → 4-[(Pyridin-2-ylamino)carbonyl]-2-phenylbenzoyl methionine methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminopyridine | HCID 10439 | — |
| 反応物 | 3-hydroxy-1,2,3-benzotriazin-4(3H)-one | HCID 73026 | — |
| 反応物 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 反応物 | 4-Carboxy-2-phenylbenzoyl methionine methyl ester | HCID 20622825 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-[(Pyridin-2-ylamino)carbonyl]-2-phenylbenzoyl methionine methyl ester | HCID 20622840 | — |
反応手順
To a solution of the resultant acid from Example 60A (1.0 equivalent) in DMF is added 3-hydroxy-1,2,3-benzotriazin-4(3H)-one (1.5 equivalents) followed by 2-aminopyridine (1.0 equivalent) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.5 equivalents). When judged complete by TLC analysis, the reaction is taken up in ethyl acetate which is washed by 1N HCl and saturated brine, and then is dried and evaporated. The crude reaction mixture is purified by column chromatography to afford the title product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06693123B2 |
| 出典データセット | uspto-grants-2004_02 |
| ORD ID | ord-b48f38b136b14362abf1d01ab24726fb |
| 出典メモ | uspto-grants-2004_02 |