L-Methionine, methyl ester, hydrochloride → [4-(3-Pyridylmethyloxymethyl)-2-phenylbenzoyl]methionine methyl ester

HRID 2121159Notes

Reaction equation

HRID 2121159 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][O:8][CH2:9][C:10]2[CH:18]=[CH:17][C:13]([C:14](O)=[O:15])=[C:12]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)[CH:11]=2)[CH:2]=1.Cl.[CH3:26][O:27][C:28](=[O:35])[C@H:29]([CH2:31][CH2:32][S:33][CH3:34])[NH2:30]>>[CH3:26][O:27][C:28](=[O:35])[C@H:29]([CH2:31][CH2:32][S:33][CH3:34])[NH:30][C:14](=[O:15])[C:13]1[CH:17]=[CH:18][C:10]([CH2:9][O:8][CH2:7][C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)=[CH:11][C:12]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 11435579L-Methionine, methyl ester, hydrochlorideHCID 234361714-(3-Pyridylmethyloxymethyl)-2-phenylbenzoic acid

Product 1

HCID 54010286[4-(3-Pyridylmethyloxymethyl)-2-phenylbenzoyl]methionine methyl ester

Procedure

The desired compound was prepared by coupling of 4-(3-pyridylmethyloxymethyl)-2-phenylbenzoic acid with methionine methyl ester hydrochloride as described in Example 163D.

Sources & evidence

ORD record
ord-a5e4a289c1e34cda8109afc5f64611ef
Source dataset
uspto-grants-2004_02
Patent number
US06693123B2

Reaction notes

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