反应详情

The desired compound was prepared by saponification of the compound of Example 240F using the procedure of Example 159. 1H NMR (300 MHz, DMSO-d6) δ 8.69 (bs, 1H), 8.55 (bd, 1H), 8.39 (d, 1H), 7.88 (dt, 1H), 7.40 (m, 6H), 7.07 (dd, 1H), 7.03 (d, 1H), 5.17 (s, 2H), 4.28 (ddd, 1H), 2.25 (m, 2H), 2.00 (s, 3H), 1.84 (m, 2H). MS (CI, NH3) m/e 454 (M+NH4)+, 437 (M+H)+, 419, 320, 288. Anal calcd for C24H24N2O4S (+0.23 H2O): C, 65.42; H, 5.59; N, 5.99. Found: C, 65.41; H, 5.42; N, 5.99.