Sodium Hydroxide → HCID 69891623, compound

Participants

Reaction Steps

To a solution of {4-[2-(pyrid-3-yl)ethenyl]-2-(2-methylphenyl)benzoyl}methionine methyl ester, prepared as in Example 274, (3.285 g, 7.13 mmol) in methanol (10 mL) was added a solution of sodium hydroxide (0.979 N, 7.35 mL). After 15 hours, the solvent was evaporated in vacuo to give the title compound (3.35 g, 100%). 1H NMR (300 MHz, DMSO-d6) δ 8.79 (d, 1H), 8.46 (dd, 1H), 8.05 (dt, 1H), 7.70-7.53 (m, 3H), 7.48-7.37 (m, 4H), 7.27-7.18 (m, 3H), 6.97 (m, 1H), 3.50 (m, 1H), 2.21, 2.03 (2 s's, 3H), 2.00-1.92 (m, 2H), 1.93 (s, 3H), 1.70 (m, 1H), 1.58 (m, 1H). MS (APCI) m/e 445 (M−H)− as the acid form.

Provenance & Evidence